Foti G, Sangalli F, Berra L, Sironi S, Cazzaniga M, Rossi GP, Bellani G, Pesenti A. Intensive Care Med. 2009 Apr;35(4):656-62
Comparison of application of CPAP by helmet in combination to medical therapy or used as a stand-alone procedure. In 62 patients split across the two groups, CPAP significantly improved oxygenation, reduced respiratory rate and improved hemodynamics. Based on results, authors propose 'helmet CPAP as first line pre-hospital treatment of presumed severe ACPE'.
Link to abstract.
Bellani G, Patroniti N, Greco M, Foti G, Pesenti A. Minerva Anestesiol. 2008 Nov;74(11):651-6
Review focusing on the properties of the helmet and the issues related to its use for the treatment of cardiogenic and non-cardiogenic pulmonary edema.
Link to abstract.
Conti G, Cavaliere F, Costa R, Craba A, Catarci S, Festa V, Proietti R, Antonelli M. Respir Care. 2007 Nov;52(11):1463-71
Comparison of the efficacy of NPPV delivered to 25 patients via helmet, matched with 25 controls chosen from historical patients treated with face mask. Authors conclude that NPPV by helmet can be 'an alternative to conventional ventilation'.
Link to abstract.
Antonelli M, Conti G, Esquinas A, Montini L, Maggiore SM, Bello G, Rocco M, Maviglia R, Pennisi MA, Gonzalez-Diaz G, Meduri GU. Crit Care Med. 2007 Jan;35(1):18-25
Prospective multi-centre cohort study across three European intensive care units with NPPV expertise, resulted in survey of 479 patients with ARDS. Authors conclude NPPV applied as first-line intervention avoided intubation in 54% of treated patients.
Link to abstract.
Masip J, Roque M, Sánchez B, Fernández R, Subirana M, Expósito JA. JAMA. 2005 Dec 28;294(24):3124-30
Meta-analysis of 15 relevant randomised controlled trials and systematic reviews comparing NIV to conventional oxygen therapy in patients with acute pulmonary edema. Authors conclude that NIV 'reduces the need for intubation and mortality' in this scenario.
Link to abstract.