Patel BK, Wolfe KS, Pohlman AS, Hall JB, Kress JP. JAMA. 2016 Jun 14;315(22):2435-41
Single-centre randomised trial of 83 patients to determine whether NIV through helmet improves intubation rate among patients with ARDS. Primary outcome was proportion of patients who needed ETI, secondary outcomes included 28-day invasive ventilator-free days, ICU length of stay, and 90-day mortality. Authors conclude helmet NIV treatment resulted in a significant reduction of intubation rates as well as statistically significant reduction in 90-day mortality.
Link to abstract.
Masip J, Roque M, Sánchez B, Fernández R, Subirana M, Expósito JA. JAMA. 2005 Dec 28;294(24):3124-30
Meta-analysis of 15 relevant randomised controlled trials and systematic reviews comparing NIV to conventional oxygen therapy in patients with acute pulmonary edema. Authors conclude that NIV 'reduces the need for intubation and mortality' in this scenario.
Link to abstract.
Squadrone V, Coha M, Cerutti E, Schellino MM, Biolino P, Occella P, Belloni G, Vilianis G, Fiore G, Cavallo F, Ranieri VM. JAMA. 2005 Feb 2;293(5):589-95
Randomised, controlled, unblinded study on 209 patients randomyl assigned to receive oxygen or oxygen plus CPAP via helmet. Primary end point was incidence of endotracheal intubation. Authors conclude that CPAP via helmet 'may decrease the incidence of endotracheal intubation' in this scenario.
Link to abstract.