Brambilla AM, Aliberti S, Prina E, Nicoli F, Forno MD, Nava S, Ferrari G, Corradi F, Pelosi P, Bignamini A, Tarsia P, Cosentini R. Intensive Care Med. 2014 Jul;40(7):942-9
Multi-centre, randomised controlled trial across four Italian centres. Patients split into helmet CPAP and Venturi mask groups. Primary end point was percentage of patients meeting criteria for ETI. Authors conclude helmet CPAP reduces the risk of meeting ETI criteria in this scenario.
Link to abstract.
Squadrone V, Massaia M, Bruno B, Marmont F, Falda M, Bagna C, Bertone S, Filippini C, Slutsky AS, Vitolo U, Boccadoro M, Ranieri VM. Intensive Care Med. 2010 Oct; 36(10):1666-74
Study to determine effectiveness of early CPAP delivered in the ward to prevent occurrence of ALI requiring intensive care admission for mechanical ventilation. Primary outcomes measured were need of mechanical ventilation and intubation rate among patients requiring ICU admission. Authors conclude early CPAP in this scenario prevents 'evolution to acute lung injury'.
Link to abstract.
Foti G, Sangalli F, Berra L, Sironi S, Cazzaniga M, Rossi GP, Bellani G, Pesenti A. Intensive Care Med. 2009 Apr;35(4):656-62
Comparison of application of CPAP by helmet in combination to medical therapy or used as a stand-alone procedure. In 62 patients split across the two groups, CPAP significantly improved oxygenation, reduced respiratory rate and improved hemodynamics. Based on results, authors propose 'helmet CPAP as first line pre-hospital treatment of presumed severe ACPE'.
Link to abstract.
Principi T, Pantanetti S, Catani F, Elisei D, Gabbanelli V, Pelaia P, Leoni P. Intensive Care Med. 2004 Jan;30(1):147-50
Comparison study of nCPAP through helmet vs face mask on 17 patients with moderate to severe acute respiratory failure. Arterial oxygen saturation, heart rate, respiratory rate and blood pressure were measured. Authors conclude early nCPAP with helmet imrpoves oxygentation in this scenario.
Link to abstract.
Tonnelier JM, Prat G, Nowak E, Goetghebeur D, Renault A, Boles JM, L'her E. Intensive Care Med. 2003 Nov;29(11):2077-80
Prospective pilot study on 11 adult patients with acute hypoxemic respiratory failure, treated with helmet CPAP, matched with 11 control patients treated with standard face mask. Primary end points were improvements of gas exchanges and clinical parameters of respiratory distress. Authors conclude the helmet is an 'efficient alternative' to face mask treatment 'even in cases of severe respiratory acidosis and hypercapnia'.
Link to abstract.