Patel BK, Wolfe KS, Pohlman AS, Hall JB, Kress JP. JAMA. 2016 Jun 14;315(22):2435-41
Single-centre randomised trial of 83 patients to determine whether NIV through helmet improves intubation rate among patients with ARDS. Primary outcome was proportion of patients who needed ETI, secondary outcomes included 28-day invasive ventilator-free days, ICU length of stay, and 90-day mortality. Authors conclude helmet NIV treatment resulted in a significant reduction of intubation rates as well as statistically significant reduction in 90-day mortality.
Link to abstract.
Rocco M, Dell'Utri D, Morelli A, Spadetta G, Conti G, Antonelli M, Pietropaoli P.Chest. 2004 Nov; 126(5):1508-15
Case-control study of 19 immunocompromised patients treated with NPPV through a helmet vs 19 controls treated through a face mask. Authors conclude helmet represents a 'valid alternative' to face mask in this scenario.
Link to abstract.
Principi T, Pantanetti S, Catani F, Elisei D, Gabbanelli V, Pelaia P, Leoni P. Intensive Care Med. 2004 Jan;30(1):147-50
Comparison study of nCPAP through helmet vs face mask on 17 patients with moderate to severe acute respiratory failure. Arterial oxygen saturation, heart rate, respiratory rate and blood pressure were measured. Authors conclude early nCPAP with helmet imrpoves oxygentation in this scenario.
Link to abstract.