Brambilla AM, Aliberti S, Prina E, Nicoli F, Forno MD, Nava S, Ferrari G, Corradi F, Pelosi P, Bignamini A, Tarsia P, Cosentini R. Intensive Care Med. 2014 Jul;40(7):942-9
Multi-centre, randomised controlled trial across four Italian centres. Patients split into helmet CPAP and Venturi mask groups. Primary end point was percentage of patients meeting criteria for ETI. Authors conclude helmet CPAP reduces the risk of meeting ETI criteria in this scenario.
Link to abstract.
Barbagallo M, Ortu A, Spadini E, Salvadori A, Ampollini L, Internullo E, Ziegler S, Fanelli G. Respir Care. 2012 Sep;57(9):1418-24
Randomised trial of 50 patients allocated to receive either continuous oxygen therapy or two cycles of helmet CPAP for 120 minutes. Results suggest that by the end of the second helmet treatment, patient's had a significantly higher PaO2/FiO2 but the improvement in oxygenation was not lasting. However, helmet CPAP was 'secure and well tolerated'.
Link to abstract.
Garuti G, Bandiera G, Cattaruzza MS, Gelati L, Osborn JF, Toscani S, Confalonieri M, Lusuardi M.
Monaldi Arch Chest Dis. 2010 Dec;73(4):145-51
Prospective observational study investigating effect of CPAP prior to admission to emergency room, on reduction of endotracheal intubation, in-hospital mortality and length of stay. Results showed that mortality was reduced when helmet CPAP was applied both in the pre-hospital and in-hospital settings. Authors conclude that using CPAP by trained nurses is 'safe, reduces mortality and hospital length of stay'.
Link to abstract.
Cosentini R, Brambilla AM, Aliberti S, Bignamini A, Nava S, Maffei A, Martinotti R, Tarsia P, Monzani V, Pelosi P.
Chest. 2010 Jul;138(1):114-20
Multi-centre, randomised controlled trial. 47 patients admitted to ED with moderate hypoxemic acute respiratory failure (ARF) due to community-acquired pneumonia (CAP) were split into helmet CPAP or standard oxygen therapy groups. Primary end point was time to reach PaO2/FiO2 ratio > 315. The proportion of patients who reached the primary end point was also recorded. Authors conclude that CPAP delivered by helmet rapidly improves oxygenation in this scenario.
Link to abstract.
Foti G, Sangalli F, Berra L, Sironi S, Cazzaniga M, Rossi GP, Bellani G, Pesenti A. Intensive Care Med. 2009 Apr;35(4):656-62
Comparison of application of CPAP by helmet in combination to medical therapy or used as a stand-alone procedure. In 62 patients split across the two groups, CPAP significantly improved oxygenation, reduced respiratory rate and improved hemodynamics. Based on results, authors propose 'helmet CPAP as first line pre-hospital treatment of presumed severe ACPE'.
Link to abstract.