Squadrone V, Massaia M, Bruno B, Marmont F, Falda M, Bagna C, Bertone S, Filippini C, Slutsky AS, Vitolo U, Boccadoro M, Ranieri VM. Intensive Care Med. 2010 Oct; 36(10):1666-74
Study to determine effectiveness of early CPAP delivered in the ward to prevent occurrence of ALI requiring intensive care admission for mechanical ventilation. Primary outcomes measured were need of mechanical ventilation and intubation rate among patients requiring ICU admission. Authors conclude early CPAP in this scenario prevents 'evolution to acute lung injury'.
Link to abstract.
Conti G, Cavaliere F, Costa R, Craba A, Catarci S, Festa V, Proietti R, Antonelli M. Respir Care. 2007 Nov;52(11):1463-71
Comparison of the efficacy of NPPV delivered to 25 patients via helmet, matched with 25 controls chosen from historical patients treated with face mask. Authors conclude that NPPV by helmet can be 'an alternative to conventional ventilation'.
Link to abstract.
Antonelli M, Conti G, Esquinas A, Montini L, Maggiore SM, Bello G, Rocco M, Maviglia R, Pennisi MA, Gonzalez-Diaz G, Meduri GU. Crit Care Med. 2007 Jan;35(1):18-25
Prospective multi-centre cohort study across three European intensive care units with NPPV expertise, resulted in survey of 479 patients with ARDS. Authors conclude NPPV applied as first-line intervention avoided intubation in 54% of treated patients.
Link to abstract.
Antonelli M, Pennisi MA, Pelosi P, Gregoretti C, Squadrone V, Rocco M, Cecchini L, Chiumello D, Severgnini P, Proietti R, Navalesi P, Conti G. Anesthesiology. 2004 Jan;100(1):16-24
Study of 33 patients with COPD treated with helmet NPPV, compared with 33 historical controls treated with face mask NPPV. In the helmet group, no patients were unable to tolerate NPPV, whereas five of the control group required intubation. Authors conclude that helmet NPPV 'can be used to treat chronic COPD with acute exacerbation'.
Link to abstract.
Antonelli M, Conti G, Pelosi P, Gregoretti C, Pennisi MA, Costa R, Severgnini P, Chiaranda M, Proietti R. Crit Care Med. 2002 Mar;30(3):602-8
Prospective clinical pilot investigation on 33 patients treated with noninvasive pressure support ventilation (NPSV) delivered by helmet. Each patient was matched with two controls with ARF treated with NPSV via a facial mask. Primary end points were improvement of gas exchange, need for endotracheal intubation and the complications related to NPSV. Both groups improved oxygenation after NPSV, less patients failed NPSV and were intubated in the helmet group and less complications occured, while longer continuous application of the tecnique was possible. Authors concluded that NPSV by helmet successfully treated hypoxemic ARF, with better tolerance and fewer complications than facial mask NPSV.
Link to abstract.